Marc Iglarz Selected Research

aprocitentan

1/2021	Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet.
1/2019	Pharmacological Characterization of Aprocitentan, a Dual Endothelin Receptor Antagonist, Alone and in Combination with Blockers of the Renin Angiotensin System, in Two Models of Experimental Hypertension.

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Marc Iglarz Research Topics

Disease

15	Hypertension (High Blood Pressure) 01/2021 - 02/2002
7	Hypertrophy 01/2019 - 07/2004
7	Pulmonary Arterial Hypertension 01/2018 - 09/2012
6	Fibrosis (Cirrhosis) 01/2018 - 10/2003
6	Vascular Remodeling 01/2018 - 01/2003
6	Pulmonary Hypertension 11/2015 - 06/2006
3	Body Weight (Weight, Body) 01/2021 - 06/2006
3	Stroke (Strokes) 02/2008 - 04/2003
3	Cardiovascular Diseases (Cardiovascular Disease) 12/2007 - 10/2003
2	Edema (Dropsy) 01/2021 - 01/2017
2	Atherosclerosis 01/2018 - 08/2016
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2018 - 10/2015
2	Inflammation (Inflammations) 01/2018 - 01/2018
2	Coronary Artery Disease (Coronary Atherosclerosis) 01/2018 - 12/2007
2	Heart Failure 01/2018 - 11/2016
2	Cardiomegaly (Heart Hypertrophy) 07/2004 - 10/2003
1	Hypercapnia 01/2023
1	Alzheimer Disease (Alzheimer's Disease) 01/2023
1	Weight Gain 01/2021
1	Hypoxia (Hypoxemia) 10/2020
1	Granuloma 01/2018
1	Lung Diseases (Lung Disease) 01/2018
1	Pain (Aches) 01/2018
1	Microvascular Rarefaction 01/2018
1	Disease Progression 01/2018
1	Ventricular Remodeling 11/2015
1	Systemic Scleroderma (Systemic Sclerosis) 10/2015
1	Interstitial Lung Diseases (Interstitial Lung Disease) 10/2015
1	Obesity 01/2015
1	Proteinuria 12/2008
1	Peripheral Arterial Disease 12/2007
1	Rupture 04/2006

Drug/Important Bio-Agent (IBA)

10	macitentanIBA 10/2020 - 12/2008
7	Endothelin Receptor AntagonistsIBA 01/2021 - 06/2006
7	Endothelins (Endothelin)IBA 01/2019 - 01/2003
6	Endothelin-1 (Endothelin 1)IBA 11/2016 - 02/2002
5	SaltsIBA 01/2019 - 01/2003
4	Bosentan (Tracleer)FDA Link 01/2023 - 06/2006
4	AldosteroneIBA 01/2017 - 06/2004
3	Endothelin Receptors (Endothelin Receptor)IBA 01/2023 - 01/2017
3	Desoxycorticosterone Acetate (DOCA)FDA Link 01/2019 - 01/2003
3	Messenger RNA (mRNA)IBA 01/2018 - 04/2003
3	PPAR alphaIBA 10/2003 - 01/2003
2	aprocitentanIBA 01/2021 - 01/2019
2	Acetates (Acetic Acid Esters)FDA Link 01/2019 - 04/2003
2	Desoxycorticosterone (Deoxycorticosterone)IBA 01/2019 - 04/2003
2	selexipagIBA 01/2018 - 01/2017
2	Epoprostenol ReceptorsIBA 01/2018 - 01/2017
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 01/2018
2	Epoprostenol (Prostacyclin)FDA LinkGeneric 01/2018 - 01/2017
2	Endothelin B ReceptorIBA 11/2016 - 11/2015
2	MonocrotalineIBA 10/2015 - 06/2006
2	Rosiglitazone (Avandia)FDA Link 02/2010 - 01/2003
2	Angiotensin IIIBA 02/2008 - 02/2005
2	AngiotensinsIBA 12/2007 - 05/2002
2	Vasoconstrictor AgentsIBA 10/2004 - 04/2003
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 10/2003 - 10/2003
1	SodiumIBA 01/2021
1	Semaxinib (SU5416)IBA 10/2020
1	Tadalafil (Cialis)FDA Link 10/2020
1	ReninIBA 01/2019
1	Hydroxyproline (4 Hydroxyproline)IBA 01/2018
1	CadmiumIBA 01/2018
1	Isosorbide Dinitrate (Isordil)FDA LinkGeneric 01/2018
1	NitratesIBA 01/2018
1	Apolipoproteins E (ApoE)IBA 01/2018
1	ApolipoproteinsIBA 01/2018
1	nintedanibIBA 01/2018
1	LectinsIBA 01/2018
1	Carbon Nanotubes (Carbon Nanotube)IBA 01/2018
1	pirfenidoneIBA 01/2018
1	acetamideIBA 01/2018
1	isosorbide-5-mononitrate (Ismo)FDA LinkGeneric 01/2018
1	treprostinil FDA Link 01/2017
1	Arginine Vasopressin (Argipressin)IBA 01/2017
1	mast cell protease 4IBA 08/2016
1	Bleomycin (Blenoxane)FDA LinkGeneric 10/2015
1	Chymases (Chymase)IBA 10/2015
1	Endothelin A ReceptorIBA 10/2015
1	sarafotoxins s6IBA 10/2015
1	CytokinesIBA 10/2015
1	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2015
1	TriazinesIBA 01/2015
1	Synthetic Prostaglandins (Prostaglandin Analogues)IBA 01/2015
1	ProstaglandinsIBA 01/2015
1	compound 17IBA 09/2012
1	Valsartan (Vals)FDA Link 02/2008
1	N- ((1- ((2- (acetylthio)- 3- methyl- 1- oxobutyl)amino)- 1- cyclopentyl)carbonyl)- O- methyl- L- tyrosine ethyl esterIBA 02/2008
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 12/2007
1	CatecholaminesIBA 06/2006
1	Sildenafil Citrate (Viagra)FDA Link 06/2006
1	Phosphodiesterase InhibitorsIBA 06/2006
1	Endothelin-2IBA 04/2006
1	GonadotropinsIBA 04/2006
1	tempolIBA 07/2004
1	Superoxide DismutaseIBA 07/2004
1	Losartan (Cozaar)FDA LinkGeneric 07/2004
1	Eplerenone (Inspra)FDA LinkGeneric 06/2004

Therapy/Procedure

3	Therapeutics 11/2016 - 10/2003
1	Vascular Surgical Procedures 12/2007